Bob B. He: Two-dimensional X-ray diffraction Content Type Journal Article Category Book Review Pages 1-2 DOI 10.1007/s10698-011-9135-8 Authors George B. Kauffman, Department of Chemistry, California State University, Fresno, Fresno, CA 93740-8034, USA Journal Foundations of Chemistry Online ISSN 1572-8463 Print ISSN 1386-4238.

In 2008, Samantha Newbery, then a PhD student, discovered a hitherto confidential document: ‘Confidential: UK Eyes Only. Annex A: Intelligence gained from interrogations in Northern Ireland’ (DEFE 13/958, The National Archives (TNA)). It details the British Army’s notorious interrogations of IRA suspects that led to the eventual banning of the ‘five techniques’ that violated the UK’s international treaty obligation prohibiting the use of torture and ‘inhuman or degrading treatment or punishment’. Having decided that the document – Intelligence gained from should (...) be put in the public domain, she invited me, along with the eminent lawyer, Philippe Sands and Brian Stuart, a former Secretary to the British Joint Intelligence Committee, to contribute commentaries. I concluded that even if the document was accurate in both what it stated and in what it left out, that use of the ‘five techniques’ (tantamount to torture) was unjustified, since the normalisation and institutionalisation of torture is far worse than failing to obtain the information thus gained. Whether or not this joint paper will make a difference to UK policy concerning the use of torture remains an open question; whether or not it should is not. This piece is an example of how my book on torture, deliberately written for a public readership, has made it possible for me to make interventions in practical policy, or at least to attempt to, whether in occasional writing for eg The Chartist and the web-based Open Democracy, or directly for activist groups, eg my ‘Ethical Opinion’ for Physicians for Human Rights – Israel, Report: Holding Health to Ransom: GSS Interrogation and Extortion of Palestinian Patients at Erez Crossing (2008). (shrink)

Do any nonhuman animals have hedonically valenced experiences not directly caused by stimuli in their current environment? Do they, like us humans, experience anticipated or previously experienced pains and pleasures as respectively painful and pleasurable? We review evidence from comparative neuroscience about hippocampus-dependent simulation in relation to this question. Hippocampal sharp-wave ripples and theta oscillations have been found to instantiate previous and anticipated experiences. These hippocampal activations coordinate with neural reward and fear centers as well as sensory and cortical areas (...) in ways that are associated with conscious episodic mental imagery in humans. Moreover, such hippocampal “re- and preplay” has been found to contribute to instrumental decision making, the learning of value representations, and the delay of rewards in rats. The functional and structural features of hippocampal simulation are highly conserved across mammals. This evidence makes it reasonable to assume that internally triggered experiences of hedonic valence (IHVs) are pervasive across (at least) all mammals. This conclusion has important welfare implications. Most prominently, IHVs act as a kind of “welfare multiplier” through which the welfare impacts of any given experience of pain or pleasure are increased through each future retrieval. However, IHVs also have practical implications for welfare assessment and cause prioritization. (shrink)

"The Symons Medal—one of Canada's most prestigious honours—recognizes an individual who has made an exceptional contribution to Canadian life. The 2020 Symons Medal was awarded to Mr. Bob Rae, P.C., C.C., O.Ont, Q.C. Mr. Rae is the 20th Medallist in this series, following a formidable line of recipients. Hon. Rae's lecture is Learning from The Past, Imagining the Future: Reflections from a Political Life. Throughout the address, published in a bilingual book format, he explores such themes as Canada's improbable origins (...) as a nation; post-war emergence onto the global stage; active membership within the United Nations; and the significance of the ever-evolving Canadian constitution—a "living tree document." Welcoming remarks were made by the Honourable Premier Dennis King, while the official response was delivered by the Honourable Roy Romanow, PC, OC, SOM, QC. Hon. Rae is the 2020 recipient in part for his many years of work on humanitarian issues, most recently the Rohingya Refugee crisis, as well as his time focusing on indigenous issues and his decades of public service and teaching. He has always been deeply involved in the political life of Canada—as MP, former premier of Ontario, and interim leader of the federal Liberal Party. The Symons Medal and Lecture Series is named in honour of Professor Thomas H.B. Symons, a long-time supporter of Confederation Centre and a Board Governor. Held each fall, the medal ceremony and its associated lecture offer a national platform for an eminent Canadian to discuss the nation’s current state, shared histories, and future prospects using themes related to their professional pursuits. The award is presented at Confederation Centre of the Arts—Canada’s living monument to Canadian Confederation—in honour of the meetings of the Fathers of Confederation, who first gathered at Province House National Historic Site in the fall of 1864."--. (shrink)

Medium- and high-spin states of Pr-134 were populated using the Cd-116(Na-23, 5n) reaction and studied with the GAMMASPHERE spectrometer. Several new bands have been found in this nucleus, one of them being linked to the previously observed chiral-candidate twin-band structure. The ground state of Pr-134 could be determined through establishing a level structure that connects the two previously known long-lived isomeric states. Unambiguous spin-parity assignments for the excited states could be performed based on the known 2(-) spin-parity of the ground (...) state combined with the present experimental data. Intrinsic single-particle configurations have been assigned to the newly observed bands on the basis of the measured B(M1)/B(E2) ratios, alignments, band-crossing frequencies, bandhead spins, the observed single-particle configurations in the neighboring nuclei, and taking into account the predictions of total Routhian surface and tilted-axis cranking calculations. (shrink)

There is public support in the United States and Europe for accounting for animal welfare in national policies on food and agriculture. Although an emerging body of research has measured animals’ capacity to suffer, there has been no specific attempt to analyze how this information is interpreted by the public or how exactly it should be reflected in policy. The aim of this study was to quantify Americans’ preferences about farming methods and the suffering they impose on different species to (...) generate a metric for weighing the trade-offs between different approaches of promoting animal welfare. A survey of 502 residents of the United States was implemented using the online platform Mechanical Turk. Using respondent data, we developed the species-adjusted measure of suffering-years, an analogue of the disability-adjusted life year, to calculate the suffering endured under different farming conditions by cattle, pigs, and chickens, the three most commonly consumed animals. Nearly one-third of respondents reported that they believed animal suffering should be taken into account to a degree equal to or above human suffering. The 2016 suffering burden in the United States according to two tested conditions was approximately 66 million SAMYs for pigs, 156 million SAMYs for cattle, and 1.3 billion SAMYs for chickens. This calculation lends early guidance for efforts to reduce animal suffering, demonstrating that to address the highest burden policymakers should focus first on improving conditions for chickens. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

High-spin states have been studied in Pr-135(59), populated through the Cd-116(Na-23,4n) reaction at 115 MeV, using the Gammasphere gamma-ray spectrometer. The negative-parity yrast band has been significantly extended to spin similar to 45 (h) over bar and excitation energy 21.5 MeV, showing evidence for several rotational alignments. The positive-parity yrast band of Ce-135(58), populated through the p4n channel of this reaction, was also populated to spin similar to 38 (h) over bar and excitation energy 18 MeV. Cranking calculations indicate that (...) these nuclei are soft with respect to the triaxiality parameter gamma and that several competing nuclear shapes occur at high spin. (shrink)

This monograph articulates and defends a theory-based epistemology of modality (TEM). According to TEM, someone justifiably believe an interesting modal claim if and only if (a) she justifiably believes a theory according to which that claim is true, (b) she believes that claim on the basis of that theory, and (c) she has no defeaters for her belief in that claim. The book has two parts. In the first, the author motivates TEM, sets out the view in detail, and defends (...) it against a number of objections. In the second, the author considers whether TEM is worth accepting. To argue that it is, the author sets out criteria for choosing between modal epistemologies, concluding that TEM has a number of important virtues. However, the author also concedes that TEM is cautious: it probably implies that we are not justified in believing some interesting modal claims that we might take ourselves to be justified in believing. This raises a question about TEM's relationship to Peter van Inwagen's modal skepticism, which the author explores in detail. As it turns out, TEM offers a better route to modal skepticism than the one that van Inwagen provides. But rather than being a liability, the author argues that this is a further advantage of the view. Moreover, he argues that other popular modal epistemologies do not fare better: they cannot easily secure more extensive modal justification than TEM. The book concludes by clarifying TEM’s relationship to the other modal epistemologies on offer, contending that TEM need not be a rival to those views, but can instead be a supplement to them. (shrink)

Attitudes to our own mortality are characterized by more than just fear, suggests Bob Plant.

Zhihe Wang (Wang Zhihe in Chinese order) is the primary mover of process thought in China today. While John B. Cobb Jr. and David Griffin are poster scholars of the movement, it is Wang who makes things happen, from the Process Academies to international conferences on topics ranging from ecological civilization to education. At my last count, there were six “Whitehead Wisdom Education Kindergartens” in Beijing. While Wang Zhihe has contributed to three other books in the Ontos Verlag Process Thought (...) series, this is his first monograph there, and it is a valuable contribution. While I want to survey the flow of the book, it is the concluding chapters that I think especially warrant our attention, for .. (shrink)

Kit Fine’s book is a study of abstraction in a quite precise sense which derives from Frege. In his Grundlagen, Frege contemplates defining the concept of number by means of what has come to be called Hume’s principle—the principle that the number of Fs is the same as the number of Gs just in case there is a one-to-one correspondence between the Fs and the Gs. Frege’s discussion is largely conducted in terms of another, similar but in some respects simpler, (...) proposal—to define the concept of direction by laying down the principle that the direction of a line a is the same as that of line b if and only if lines a and b are parallel. Such principles have come to be known as abstraction principles. More generally, abstraction principles are ones of the shape: ∀α∀β ↔ α ≈ β), where ≈ is an equivalence relation on entities of the type over which α and β vary and, if the principle is acceptable, § is a function from entities of that type to objects. Since ‘the direction of’ is intended to stand for a function from objects of a certain sort to other objects, the Direction Equivalence is a first-order, or in Fine’s terminology objectual, abstraction; since ‘the number of’ is intended to stand for a function from concepts to objects, Hume’s principle is a higher-order, or as Fine says conceptual, abstraction. As is well-known, Frege himself abandoned the idea of defining number implicitly or contextually by means of Hume’s principle—adopting instead an explicit definition of the number of Fs as the extension of the concept concept equinumerous to the concept F— because he thought that an adequate definition should settle the question whether Julius Caesar, for example, is or is not the number of some concept, but that the proposed implicit definition cannot do so. But interest in abstraction principles has revived in the last couple of decades, largely as a result of Crispin Wright’s attempt to show that in spite of the many difficulties confronting it—including the notorious Julius Caesar problem— Hume’s principle can after all serve as a foundation for arithmetic. (shrink)

If mortality is the most important fact about us, then it is reasonable to think that fear of death is our most fundamental fear. Indeed, while philosophers continue to disagree about whether it is rational to fear death, they tend to assume that fear is the most common, natural response our mortality provokes. I neither want to deny the reality of this fear nor evaluate its rationality. Rather, drawing on Derrida’s remarks on ‘quasi-death’, I will argue that fearful or not, (...) death pervades everyday life; imagining one’s own death, and thereby remaining semi-present as a spectral observer, is not inherently misleading; and taking these imaginings seriously highlights another response we have toward our own mortality that is at least as significant as fear; namely, prospective, self-directed grief. (shrink)

This paper explores how fair trade social enterprises manage paradoxes in stakeholder-oriented governance models. We use narrative accounts from board members, at governance events and board documents to report an exploratory study of paradoxes in three FTSEs which are partly farmer-owned. Having synthesized the key social enterprise governance literature and framed it alongside the broader paradox theory, we used narratives to explore how tensions are articulated, how they can be applied within an adapted paradox framework, and how governance actors seek (...) to mitigate paradoxes. The paper contributes to current debates in social enterprise scholarship concerning hybridity :455–476, 2010; in Institutional logics in action, Part B, 2012), hybrid organizing :397–441, 2014) and operational tensions :407–442, 2013) by illustrating empirically how the central social/enterprise paradox manifests in FTSEs governance arrangements. We build on the paradox categories proposed by Lüscher and Lewis :221–240, 2008) and adapted in Smith et al. :407–442, 2013) by developing a recursive model of legitimacy-seeking governance processes, conceptualizing how boards seek to mitigate, but not necessarily resolve, paradoxes. (shrink)

If David Lewis's modal realism is true, then there are many, many people. According to Mark Heller, this is bad news. He takes modal realism (MR) to imply that "there are at least some cases in which it is permissible to let drowning children drown when it would be easy to save them." But since he holds the reasonable view that this is never permissible, he thinks that MR is false. Here, I argue that Lewis needn't be troubled by this (...) objection, and that it provides no reason to reject MR for those who share Lewis's moral outlook. Moreover, I argue that disagreement with common sense needn't be severe if we can show both (a) that there's a sense in which common sense is correct and (b) we have little reason to care about the sense in which common sense is mistaken. (shrink)

Søren Kierkegaard is well known for his claim that human life is marked by three existential spheres — the aesthetic, the ethical, and the religious. In Bob Dylan and the Spheres of Existence, Christopher B. Barnett argues that Kierkegaard's theory provides a key interpretative lens through which to evaluate the songwriting of Bob Dylan.

: From its founding in 1847, the AMA divided drugs into "ethical" and "unethical" preparations. Those that were ethical had a known composition and were advertised only to the profession. Others, patent medicines (technically proprietary drugs, whose trademarks were protected by copyright), were sold directly to the public. In spite of the AMA's efforts to ban the advertising and sale of these nostrums, proprietary drugs flourished during the nineteenth century. Starting in 1900, however, three major societal trends combined to bolster (...) the AMA's campaign, and by 1920 almost all advertising was directed to physicians, who would then prescribe medications to their patients. This ban on advertising pharmaceuticals directly to the public remained virtually unchanged until approximately 1980. Since then, it has slowly eroded and, as recently as 1997, the FDA created guidelines for pharmaceutical companies to advertise on television. What does this change say about the profession of medicine, the role of the physician in society, and the doctor-patient relationship? Using a comparative historical approach, this paper examines these issues. (shrink)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early (...) cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150–350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing. (shrink)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early (...) cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150–350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hypermediated Art CriticismPamela G. Taylor (bio) and B. Stephen Carpenter II (bio)Technological media catapults our perception into what Marshall McLuhan called "new transforming vision and awareness."1 As our lives become more and more immersed in such technologies as television, film, and interactive computers, we find ourselves inundated with a heightened sense of mindfulness—an aesthetic experience made possible through such computer technological characteristics as hyperlinks, hypermedia, and hyperreality. In these (...) terms, the prefix "hyper" represents various linking devices inherent to computer technology that allure and transport us between, above, below, and toward vast areas of information, places, and peoples. Hypermediacy, according to Bob Cotton and Richard Oliver, is "an entirely new kind of media experience born from the marriage of TV and computer technologies. Its raw ingredients can be brought together in any combination. It is a medium that offers random access; it has no physical beginning, middle, or end."2 In other words, there is no set or static structure inherent in technological media. It is not so much an "anything goes" apparatus as it is an "anything is possible" system. The seemingly vast possibilities inherent to technological media offer us many and alternate views of the world.Just as technological media encourage multiple means of viewing the world, no single approach to art criticism can be considered dominant, as several methods, methodologies, and approaches exist for responding to [End Page 1] works of art. We conceive of art criticism as a complex means of making meanings about works of art and communicating those meanings to other people. Following the lead of art educator Terry Barrett,3 art criticism hinges on the four activities of describing, interpreting, judging, and theorizing about art. Barrett suggests that, although all four overlap, interpretation is the most important and most likely the most complex aspect of art criticism. Although interwoven with description, analysis, and judgment, interpretation of the meanings of individual works of art is of foremost concern in contemporary art criticism. Similarly, we situate hypermediated art criticism as a synthesis of our descriptions, interpretations, judgments, and theories—both verbal and visual—with the various ways in which computer technology facilitates the simultaneous existence, representation, storage, and presentation of these and other forms of meaning making about works of art.Hypermediated art criticism is built upon our own technological abilities to both create and follow divergent paths, ideas, and beliefs according to our choices. Hypermediated art criticism is inclusive of the ways that our choices change daily depending upon our situation, role, and purpose, or simply as a result of what we witness or experience in a moment. In the hypermediated criticism process, our ways of seeing and knowing change from a linear to multilinear perspective, from single to multilayered, and from static to mutable perception. Indeed, the disparate ways of seeing and knowing made possible through technological media and hypermedia provide us with an expansive and personally reflective approach to art criticism.Personal Reflection and Art CriticismMichael Joyce, known for his poetic approach to computer hypertext theory and fictional writing, says, "We are who we are. Layered and overlaid, we make a world within our bodies."4 Possibly now more than ever that world within our bodies can be represented, re-presented, and re-invented right before our eyes through technological media. Digital ethnographer Ricki Goldman-Segall refers to this technological world as a learning constellation in which "we are each composed of many selves, all of which interact with each other as we learn.... With the use of new computer technologies, we extend not only our technological abilities, but also our various personae—the societies of our minds—in the form of new objects for others to think with."5 In the classroom, hypermediated art criticism generated through computer technology functions just this way—as new objects that we, and our students, use to help us extend the ways in which we think about works of art.Contrary to the antihumanist approach so often associated with computer technology theory,6 our discussion of hypermediated art criticism—the symbiotic relationship of art criticism and technology—begins with the [End Page 2] basic assumption that a primary purpose of... (shrink)

This book explores two questions that are integral to the question of the existence of God. The first question concerns the meaning of "existence" and the second concerns the meaning of "God". Regarding the first question, this book motivates, presents and defends the meta-ontology found in Gottlob Frege's writings and defended by Michael Dummett, Crispin Wright and Bob Hale. Frege's approach to questions of existence has mainly found use in connection with abstract objects such as numbers. This is one of (...) the first studies to systematically present Fregean meta-ontology and apply it to theology. Frege's meta-ontology is informed by his context principle. According to this, logico-syntactic notions such as "singular term" and "predicate" are pivotal to questions of what exists. These notions serve to throw light on the second question. Through thorough engagement with Old as well and New Testament texts, the book shows how Frege's logico-syntactic notions are of crucial importance when seeking to understand the meaning and use of "God". To complete the defence of Fregean meta-ontology, the book concludes by pointing to important differences between the otherwise closely associated concepts of an object found in Wittgenstein's Tractatus Logico-Philosophicus and Frege's writings. (shrink)

The fourteen papers in this collection offer a variety of original contributions to the epistemology of modality. In seeking to explain how we might account for our knowledge of possibility and necessity, they raise some novel questions, develop some unfamiliar theoretical perspectives, and make some intriguing proposals. Collectively, they advance our understanding of the field. In Part I of this Introduction, I give some general background about the contemporary literature in the area, by sketching a timeline of the main tendencies (...) of the past twenty-five years or so, up to the present debates. Next, I focus on four features that largely characterize the latest literature, and the papers in the present collection in particular: (i) an endorsement of the importance of essentialism; (ii) a shift to a “metaphysics-first” approach to modal epistemology; (iii) a focus on metaphysical modality as opposed to other kinds of modality; and (iv) a preference for non-uniform modal epistemology. In Part II, I present the individual papers in the volume. These are organized around the following four chapters, based on their topic: (A) Skepticism & Deflationism; (B) Essentialism; (C) Non-Essentialist Accounts; (D) Applications. -/- LIST OF CONTRIBUTORS: Francesco Berto; Stephen Biggs & Jessica Wilson; Justin Clark-Doane; Philip Goff; Bob Hale; Frank Jackson; Mark Jago; Boris Kment; Antonella Mallozzi; Graham Priest; Gabriel Rabin; Amie Thomasson; Anand Vaidya & Michael Wallner; Jennifer Wang. -/- The volume is dedicated to the memory of Bob Hale. -/- . (shrink)

This essay argues for a 'relationist' treatment of intentional identity sentences like (1) "Hob believes that a witch blighted Bob's mare and Nob believes that she killed Cob's sow" (Geach 1967). According to relationism, facts of the form "a believes that p and b believes that q" are not in general reducible to facts of the form "c believes that r". We first argue that extant, non-relationist treatments of intentional identity are unsatisfactory, and then go on to motivate and explore (...) a relationist alternative in some detail. We show that the general thesis of relationism can be directly motivated via cases already discussed in the literature, and then develop a particular version of relationism couched in the possible worlds framework. The resulting theory avoids the problems facing its non-relationist rivals, and yields a natural account of the truth-conditions of (1), truth-conditions which can be generated in a compositional manner by a version of dynamic semantics. The theory also helps us to cleanly separate semantic questions about intentional identity from metasemantic ones. (shrink)

ABSTRACT According to contemporary diagnoses, democracy is foundering because of polarization. It is natural to think that if polarization is a problem, the remedy is to reconcile the conflicting sides. Yet reconciliation seems to involve the disturbing prescription that citizens should reconcile with radicals who have divested from democratic norms. That assumes, however, that polarization is symmetrical, whereby each side is equally responsible for it. But polarization need not depend on the assumption of such symmetry, such that depolarization may be (...) possible without reconciliation. If so, polarization may be a problem not only between political alliances but within them. (shrink)

The Myelin Regulator Factor (MYRF) is a master regulator governing myelin formation and maintenance in the central nervous system. The conservation of MYRF across metazoans and its broad tissue expression suggest it has functions extending beyond the well‐established role in myelination. Loss of MYRF results in developmental lethality in both invertebrates and vertebrates, and MYRF haploinsufficiency in humans causes MYRF‐related Cardiac Urogenital Syndrome, underscoring its importance in animal development; however, these mechanisms are largely unexplored. MYRF, an unconventional transcription factor, begins (...) embedded in the membrane and undergoes intramolecular chaperone mediated trimerization, which triggers self‐cleavage, allowing its N‐terminal segment with an Ig‐fold DNA‐binding domain to enter the nucleus for transcriptional regulation. Recent research suggests developmental regulation of cleavage, yet the mechanisms remain enigmatic. While some parts of MYRF's structure have been elucidated, others remain obscure, leaving questions about how these motifs are linked to its intricate processing and function. (shrink)

Correlations of spins in a system of entangled particles are inconsistent with Kolmogorov’s probability theory (KPT), provided the system is assumed to be non-contextual. In the Alice–Bob EPR paradigm, non-contextuality means that the identity of Alice’s spin (i.e., the probability space on which it is defined as a random variable) is determined only by the axis $\alpha _{i}$ chosen by Alice, irrespective of Bob’s axis $\beta _{j}$ (and vice versa). Here, we study contextual KPT models, with two properties: (1) Alice’s (...) and Bob’s spins are identified as $A_{ij}$ and $B_{ij}$ , even though their distributions are determined by, respectively, $\alpha _{i}$ alone and $\beta _{j}$ alone, in accordance with the no-signaling requirement; and (2) the joint distributions of the spins $A_{ij},B_{ij}$ across all values of $\alpha _{i},\beta _{j}$ are constrained by fixing distributions of some subsets thereof. Of special interest among these subsets is the set of probabilistic connections, defined as the pairs $\left( A_{ij},A_{ij'}\right) $ and $\left( B_{ij},B_{i'j}\right) $ with $\alpha _{i}\not =\alpha _{i'}$ and $\beta _{j}\not =\beta _{j'}$ (the non-contextuality assumption is obtained as a special case of connections, with zero probabilities of $A_{ij}\not =A_{ij'}$ and $B_{ij}\not =B_{i'j}$ ). Thus, one can achieve a complete KPT characterization of the Bell-type inequalities, or Tsirelson’s inequalities, by specifying the distributions of probabilistic connections compatible with those and only those spin pairs $\left( A_{ij},B_{ij}\right) $ that are subject to these inequalities. We show, however, that quantum-mechanical (QM) constraints are special. No-forcing theorem says that if a set of probabilistic connections is not compatible with correlations violating QM, then it is compatible only with the classical–mechanical correlations. No-matching theorem says that there are no subsets of the spin variables $A_{ij},B_{ij}$ whose distributions can be fixed to be compatible with and only with QM-compliant correlations. (shrink)

Bell inequalities are usually derived by assuming locality and realism, and therefore violations of the Bell-CHSH inequality are usually taken to imply violations of either locality or realism, or both. But, after reviewing an oversight by Bell, in the Corollary below we derive the Bell-CHSH inequality by assuming only that Bob can measure along vectors b and b' simultaneously while Alice measures along either a or a', and likewise Alice can measure along vectors a and a' simultaneously while Bob measures (...) along either b or b', without assuming locality. The violations of the Bell-CHSH inequality therefore only mean impossibility of measuring along b and b' simultaneously. (shrink)

Short’s assertion that Peirce lacked a cohesive philosophical system is critically examined, and the interconnectedness of Peirce’s 1884–1893 “cosmology” with other aspects of his work is explored, countering Short’s claims of its limited systematic relevance. Additionally, Short’s claim that Peirce “expanded empiricism empirically” is scrutinized, and his interpretation of Peirce’s account of perception is criticized. By contrasting Short’s anti-system reading, I highlight the importance of studying Peirce’s philosophy holistically.

The unbridled positivity toward curiosity and creativity may be excessive. Both aid species survival through exploration and advancement. These beneficial effects are well documented. What remains is to understand their optimal levels and contexts for maximal achievement, health, and well-being. Every beneficial element to individuals and groups carries the potential for harm – curiosity and creativity included.

This chapter contains section titled: Further Reading Notes.

This article concerns the ongoing neo-logicist program in the philosophy of mathematics. The enterprise began life, in something close to its present form, with Crispin Wright’s seminal [1983]. It was bolstered when Bob Hale [1987] joined the fray on Wright’s behalf and it continues through many extensions, objections, and replies to objections . The overall plan is to develop branches of established mathematics using abstraction principles in the form: Formula where a and b are variables of a given type , (...) Σ is a higher-order operator denoting a function from items of the given type to objects in the range of the first-order variables, and E is an equivalence relation over items of the given type. In what follows, I will sometimes omit the initial quantifiers.Frege [1884, 1893] himself employed three abstraction principles. One of them, used for illustration, comes from geometry: "The direction of l1 is identical to the direction of l2 if and only if l1 is parallel to l2."Call this the direction principle. The second was dubbed N= in [Wright, 1983] and is now called Hume’s principle: Formula where F≈G is an abbreviation of the second-order statement that there is a one-to-one relation mapping the F’s onto the G’s. In words, states that the number of F is identical to the number of G if and only if F is equinumerous with G. Unlike the direction-principle, the relevant variables, F, G here are second-order. Georg Cantor …. (shrink)

The fourteen papers in this collection offer a variety of original contributions to the epistemology of modality. In seeking to explain our knowledge of possibility and necessity, they raise some novel questions, develop some unfamiliar theoretical perspectives, and make some intriguing proposals. In the Introduction (penultimate draft available for download), I give some general background about the contemporary literature in the area, by sketching a timeline of the main tendencies of the past twenty-five years or so, up to the present (...) debates. Next, I focus on four features that largely characterize the latest literature, and the papers in the present collection in particular: (i) an endorsement of the importance of essentialism; (ii) a shift to a “metaphysics-first” approach to modal epistemology; (iii) a focus on metaphysical modality as opposed to other kinds of modality; and (iv) a preference for non-uniform modal epistemology. Then I turn to present the individual papers in the volume, which are organized based on their topic around the following four chapters: (A) Skepticism & Deflationism; (B) Essentialism; (C) Non-Essentialist Accounts; (D) Applications. LIST OF CONTRIBUTORS: Francesco Berto; Stephen Biggs & Jessica Wilson; Justin Clark-Doane; Philip Goff; Bob Hale; Frank Jackson; Mark Jago; Boris Kment; Antonella Mallozzi; Graham Priest; Gabriel Rabin; Amie Thomasson; Anand Vaidya & Michael Wallner; Jennifer Wang. The volume is dedicated to the memory of Bob Hale. (shrink)

While the need to protect vulnerable research participants is universal, conceptual challenges with the notion of vulnerability may result in the under or over-protection of participants. Ethics review bodies making assumptions about who is vulnerable and in what circumstance can be viewed as paternalistic if they do not consider participant viewpoints. Our study focuses on participant vulnerability in Scholarship of Teaching and Learning (SoTL) research. We aim to illuminate students’ views on participant vulnerability to contribute to critical analysis of the (...) role and processes of ethics review. Additionally, we aim to highlight the importance of seeking the views of participant communities, especially in research environments beyond ethics review’s medical origins. Thirty-four students from a health-related faculty at a university in Aotearoa New Zealand, participated in five focus groups. Participants discussed factors affecting their potential participation in research drawing upon a series of vignettes based on examples of published SoTL projects. Themes, generated using reflexive thematic analysis, built a participant-informed picture of vulnerability. Findings indicate that students do not generally consider themselves vulnerable and instead consider participation in SoTL research through an agentic lens. Students expect that participation will be voluntary, not negatively impact their grades, and not single them out so that others could judge them. Our study also highlights the value students place on relationships with one another and teaching staff and the implications these have for SoTL research participation and future professional practice. This research challenges research ethics committees to think further about vulnerability in the context of SoTL whilst highlighting the importance of providing opportunities for research participants more broadly to explore and vocalize their views as members of participant communities. (shrink)